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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TUBB1 All Species: 63.33
Human Site: S176 Identified Species: 99.52
UniProt: Q9H4B7 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H4B7 NP_110400.1 451 50327 S176 V M P S P K V S D T V V E P Y
Chimpanzee Pan troglodytes Q8WP14 444 49773 S176 I L P S P K V S D T V V E P Y
Rhesus Macaque Macaca mulatta XP_001082345 451 50234 S176 V M P S P K V S D T V V E P Y
Dog Lupus familis XP_543075 458 50159 S176 V L P S P K V S D T V V E P Y
Cat Felis silvestris
Mouse Mus musculus Q9ERD7 450 50400 S176 V V P S P K V S D T V V E P Y
Rat Rattus norvegicus Q6P9T8 445 49782 S176 V V P S P K V S D T V V E P Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511352 452 50925 S176 I M P S P K V S D T V V E P Y
Chicken Gallus gallus P09207 446 50135 S176 V V P S P K V S D T V V E P Y
Frog Xenopus laevis P13602 443 49705 S176 V M P S P K V S D T V V E P Y
Zebra Danio Brachydanio rerio XP_686874 466 52560 S176 V M P S P K V S D T V V E P Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24560 447 50129 S176 V V P S P K V S D T V V E P Y
Honey Bee Apis mellifera XP_392313 447 50157 S176 V V P S P K V S D T V V E P Y
Nematode Worm Caenorhab. elegans P41937 444 49782 S176 V V P S P K V S D T V V E P Y
Sea Urchin Strong. purpuratus XP_791790 447 50098 S176 V V P S P K V S D T V V E P Y
Poplar Tree Populus trichocarpa
Maize Zea mays P18025 446 49944 S176 V F P S P K V S D T V V E P Y
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.6 98.6 81 N.A. 77.8 78 N.A. 87.6 83.5 77.8 76.1 N.A. 78 77.8 76.7 78.2
Protein Similarity: 100 86.9 99.3 91.4 N.A. 89.1 88.2 N.A. 94.2 91.8 88.2 87.7 N.A. 88.9 88.9 88 88.4
P-Site Identity: 100 86.6 100 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 100 100 N.A. 93.3 93.3 93.3 93.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 100 100 100
Percent
Protein Identity: N.A. 73.1 N.A. N.A. N.A. N.A.
Protein Similarity: N.A. 85.5 N.A. N.A. N.A. N.A.
P-Site Identity: N.A. 93.3 N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. 93.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 34 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 100 0 100 0 0 0 0 0 0 0 0 100 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 100 0 0 0 100 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 % T
% Val: 87 47 0 0 0 0 100 0 0 0 100 100 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _